UK boost for South Africa in new struggle against AIDS

  • Author: Health Informer
  • Filed under: Health News
  • Date: Nov 30,2008

South Africa’s revitalised drive against AIDS today received a £15 million boost which could help save millions of lives and stop the spread of HIV across the country.

International Development Minister Ivan Lewis travelled to Johannesburg ahead of World AIDS Day to offer the new South African Health Minister, Barbara Hogan, direct UK support as she embarks upon a new drive to tackle the HIV epidemic.

Ms Hogan’s recent appointment has signalled a significant change in direction in the fight against HIV and AIDS after years of inaction, misinformation and denial.

Ivan Lewis said:

“For too long, South Africa has been fighting AIDS with its hands tied behind its back – with over 5.5 million people living with HIV. Those ties have now been removed and the country has a real opportunity finally to turn the tide in its struggle against this epidemic.

“Barbara Hogan has set a bold and exciting vision on HIV and AIDS and that is why the UK is fully committed to working with her as she embarks on this new approach. We must ensure this new direction is irreversible and that there are no more lost opportunities to save lives.

“If we manage to control and then reverse HIV and AIDS in South Africa there will be a positive knock-on effect across Southern Africa and the continent. I call on the people of South Africa to unite behind this effort and finally call time on the HIV epidemic.”

The UK support plan will help South Africa deliver:

  • More protection for mothers and babies. There will be an increase in the availability of free tests for mothers during pregnancy, and anti-HIV drugs for pregnant mothers and children. Isolated and rural areas will be specifically targeted. It is estimated that over 45,000 lives could be saved every year.
  • National HIV awareness campaign. Information on safe-sex and HIV health issues will be sent out via radio, newspaper, text messages and street posters. The multi-media campaign is expected to reach 9 in 10 South Africans – over 43 million people.
  • Better nurses, doctors and clinics. Medical staff and managers will be helped to improve the quality of advice and service to patients, and staff morale improved through stronger incentives for quality care. Training will be offered to improve the quality and efficiency of services.
  • HIV and AIDS ‘watchdog’. The National AIDS Council (SANAC) will be strengthened and given a clearer remit to hold all parts of government to account, as well as frontline agencies involved in tackling HIV and delivering health services.

South Africa has the highest burden of AIDS in the world. Over 2.5 million people have died and over 5.5 million people in South Africa are living with HIV. Every day 800 people die from AIDS and 1500 people are infected with HIV – around one person every minute.

In the past the South African national response to AIDS has been severely hampered by “denialism” – the disproven theory that HIV does not cause AIDS.

The new awareness campaign “Small Acts, Many People, Big Change: We shall overcome” will be kick started by Barbara Hogan on Friday after the SANAC meeting. It will lead to and culminate in a minute’s silence followed by a national work stoppage on World AIDS Day to start a national conversation on AIDS.

The UK is a leader in the global effort to tackle AIDS. In South Africa, DFID Is concluding a major 5-year programme on AIDS and has spent £30 million to strengthen AIDS responses at national and provincial level. A new 5-year programme will start in mid-2009.

DFID, the Department for International Development: leading the British government’s fight against world poverty. One in five people in the world today, over 1 billion people, live in poverty on less than one dollar a day.

Website: www.dfid.gov.uk

Source: Department for International Development


eTIPs – electronic-Targeted Intervention for Psoriasis

  • Author: Health Informer
  • Filed under: Health News
  • Date: Nov 29,2008

Psoriasis affects 2-3% of people in the UK and can create both physical and psychological distress. Psychological discomfort is made worse by the visible nature of the condition whereby some people avoid exposing their skin and avoid social activity due to embarrassment. The University of Manchester has embarked on a PAPAA (Psoriasis and Psoriatic Arthritis Alliance) funded study to help people manage psoriasis better. The research team includes skin and psychology experts Professor Chris Griffiths, Professor Nick Tarrier, Dr. Christine Bundy, Ms. Binder Kaur and Dr. Sandra Bucci.

The team has designed a program, known as eTIPs (electronic-Targeted Intervention for Psoriasis). This is a web-based programme for people with psoriasis which aims to reduce psychological distress and improve psoriasis, help with coping and managing psoriasis better, improve quality of life, and increase feelings of confidence and positive thinking. Participants will complete the web-based therapy over a six week period and will be required to complete questionnaires at 3 or 4 different time points (including a six month follow-up).

e-TIPs is offered to individuals diagnosed with plaque psoriasis, who are 16 years or over, have working knowledge of the English language, and have internet access. It will be delivered on-line so that it is widely available, and can reach out to individuals who may not wish to discuss psychological complaints face-to-face. Participants can take part at their own convenience and in the privacy of their own home, and can also work at their own pace.

This study which began recruiting people in the autumn 2008 will run until December 2009.

Look out for recruitment announcements via the PAPAA website (http://www.papaa.org ) and local newspapers, radio and clinics (in Manchester only).

PAPAA:

PAPAA was founded in 2007, as a joint venture between the Psoriatic Arthropathy Alliance (PAA) (Reg Charity No: 3055414), and the Psoriasis Support Trust (PST) (Reg Charity No: 1088359), with the aim of merging the original charities into a single entity, becoming a principle resource of information and help for people with psoriasis and psoriatic arthritis in the UK.

The Psoriasis and Psoriatic Arthritis Alliance (PAPAA) is a Registered Charity No: 11188192. A Company Limited by Guarantee, registered in England and Wales No: 6074887 Registered Office: Acre House 11-15 William Road London NW1 3ER.

Source: PAPAA


St. Jude Identifies Genomic Causes of a Certain Type of Leukemia Relapse

  • Author: Health Informer
  • Filed under: Health News
  • Date: Nov 28,2008

New study finds the majority of acute lymphoblastic leukemia relapse cases arise from a cell already present at the time of diagnosis

Scientists at St. Jude Children’s Research Hospital have identified distinctive genetic changes in the cancer cells of children with acute lymphoblastic leukemia (ALL) that cause relapse. The finding offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults.

The most common childhood cancer, ALL affects thousands of children annually in the United States. Although more than 80 percent of ALL cases are cured, relapse is a significant problem, with only 30 percent of children with relapsed ALL surviving.

Previous studies had found some evidence for genetic differences between the cancer cells of ALL patients at initial diagnosis and those who relapsed. That information was limited, and there had never been a broad comparison of the entire genomes of ALL at initial diagnosis and at subsequent relapse.

In the study that appears in the Nov. 28, 2008, issue of the journal Science, St. Jude researchers compared the genomes of the cancer cells of 61 childhood ALL patients when they were initially diagnosed and after they had relapsed. The investigators used millions of genetic markers — characteristic genetic variations called single nucleotide polymorphisms — as guideposts to pinpoint genetic changes characteristic of relapsed cells. Using these genetic markers, the researchers analyzed all of the cells’ chromosomes to look for genetic changes called copy number abnormalities specific to relapsed cells. These changes are considered a major type of damaging gene alterations in ALL.

“In more than 90 percent of the cases, we found differences in the genetic alterations present at the time of diagnosis and at the time of relapse,” said Charles Mullighan, M.D., Ph.D., assistant member in the St. Jude Department of Pathology and the paper’s first author. “Examining the new changes that are arising at relapse tells us a lot about the individual genetic lesions that might confer resistance to treatment and be responsible for relapse.”

According to the researchers, the relapse-related genetic changes commonly disrupted the machinery by which white blood cells called B cells mature and proliferate. Importantly, the relapse-related genetic changes only infrequently involved genes directly regulating the responsiveness to anti-cancer drugs.

The analysis also indicated that in most cases, the cancer cells responsible for relapse were related to those that originally gave rise to the cancer. Those relapse cells were present at low levels at diagnosis, the scientists’ analysis indicated. However, in a few cases, the relapse cells evolved from genetically distinct cells, indicating that the relapsed leukemia was actually an entirely new cancer.

“The key finding in our work is that in the majority of cases, relapse is arising from a cell already present at the time of diagnosis,” said James Downing, M.D., St. Jude Scientific Director, chair of the Department of Pathology and the paper’s senior author. “That cell is selected for during treatment and then subsequently emerges as basis for relapse.”

“The second key point is that we have found a large number of new genetic alterations that had not been previously identified as new targets of copy number changes at the time of relapse,” Mullighan added.

Mullighan emphasized that the findings do not mean immediate treatments for ALL relapse. “But, this is a very important starting point because we have identified several key pathways that are the most common targets of new genetic changes at the time of relapse,” he said.

Identification of these relapse pathways will lead to understanding of the biological machinery of relapse, and ultimately to drugs that target that machinery. Such studies of the relapse machinery are now underway at St. Jude.

In other further studies, the researchers are also looking for other relapse-related genetic alterations besides copy number abnormalities. They are also applying their findings to adult ALL, in which relapse is a more significant problem than in the childhood disease.

Other authors of this paper include Letha Phillips, Xiaoping Su, Jing Ma, Christopher Miller and Sheila Shurtleff.

The research was supported in part by the National Health and Medical Research Council of Australia and ALSAC.

St. Jude Children’s Research Hospital

St. Jude Children’s Research Hospital is internationally recognized for its pioneering work in finding cures and saving children with cancer and other catastrophic diseases. Founded by late entertainer Danny Thomas and based in Memphis, Tenn., St. Jude freely shares its discoveries with scientific and medical communities around the world. No family ever pays for treatments not covered by insurance, and families without insurance are never asked to pay. St. Jude is financially supported by ALSAC, its fundraising organization. For more information, please visit www.stjude.org.


Assistive Listening Devices Available Free with Hearing System Purchase Starting November 26 through December 7

Zounds Hearing, a unique manufacturing and retail company focused on providing hearing devices with state-of-the-art fidelity, price point and professional service, announces the introduction of assistive listening devices (ALDs) in an effort to aid all who are hard of hearing. The various devices are now available in all of the Zounds Hearing Centers retail locations effective November 24, 2008. And, from November 26, 2008, through December 7, 2008, all customers who purchase a Zounds hearing system will be eligible for a free ALD*.

The products include an Amplified Cordless Phone, Amplified Corded Phone, Cordless Phone Handset, Portable Phone Amplifier, Telephone Ring Signaler and Alarm Clock, all ranging in price from $34.95 to $119.95. The array of devices are available in time for the holiday season, so consumers can feel good about giving the important gift of better hearing while being easy on the pocketbook.

The ALDs feature:

  • A choice of adjustable tone levels (up to 95 dB ring level) along with sound clarifying technology to aid those with various levels of hearing loss
  • Wake & Shake features, vibrating pads and flashing lights as alternative forms of alarm-clock signaling while sleeping
  • Phones include adjustable handsets, vibrate & visual ringers and amplification adjustments, making talking on the phone convenient for those with or without a hearing loss

“Zounds is extremely excited to be incorporating these products into our growing array of hearing devices,” said John Costello, CEO of Zounds. “Along with our rechargeable Zounds hearing aids, these ALDs help give people the freedom of better hearing, no matter their situation.”

In addition to a growing product line, Zounds hearing centers are expanding with 30 retail locations across the United States. The company opened its first location in February of 2007 and plans to open many more stores in 2009 through an aggressive expansion plan.

To experience the Zounds difference, please visit a hearing center location or visit our demonstration at http://www.zoundshearing.com/.

*Products may vary by location


Give Yourself the Gift of Health This Holiday Season

Scientifically Proven Exercise Tips to Help You Beat Holiday Stress, Get Fit, Stay Healthy, and Live Longer

Scientific studies have found that exercise can decrease age-related macular degeneration, prevent or delay the onset of high blood pressure, improve your sex life, increase collagen to keep your skin younger, reduce coronary artery disease and stress, and improve overall wellness. In “Faster, Better, Stronger,” Eric Heiden, M.D., world-renowned speed skater, cyclist and orthopedic surgeon and his co-authors, outline 10 proven secrets to a healthier body in 12 weeks and highlight scientific research to support their techniques. Geared toward those 30 and above “Faster, Better, Stronger” offers training tips for every lifestyle from sedentary to very active.

“We wanted to offer people of all physical conditions an inexpensive ‘personal trainer’ that could help them reduce stress and improve their health during these pressure cooker days,” says Dr. Heiden. “Exercise, when done properly and in a specific order – combining flexibility, aerobic, strength training and balance – can help you beat weight loss and training plateaus, gain greater exercise benefits in a fraction of the time, live longer and improve your overall quality of life. Exercise really is one of the best prescriptions for staying healthy and this book guides you through the process and benefits, whether you are a competitive athlete or a recovering coach potato.”

Drs. Heiden and Massimo Testa met at Stanford University Medical School, where Heiden was a student and Testa his cycling team doctor. The two went on to develop the UC Davis Sports Performance Center and now continue their collaboration at The Orthopedic Specialty Hospital in Salt Lake City and cycling camps in Park City, Utah. Dr. Heiden is practicing orthopedic surgeon, team physician for the U.S. Speed Skating, and team physician and director of sports medicine for USA Cycling. Dr. Testa is one of the foremost cycling trainers and exercise physiologists.

“Using our medical expertise and knowledge of training competitive athletes, we have created a book that offers, simple, understandable and affordable solutions that can be personalized for each and every reader,” says Dr. Testa, a co-author. “We offer tips for fitness at the office, on a business trip or in your living room, as well as highlights the prescriptive aspects of exercise, the biology of movement and the importance of motivation.”

“Faster, Better, Stronger,” offers readers, self-assessment tools, diagrams of innovative exercises, and other straight talk on exercise and your health,” says Dr. Heiden. “Whether you are a working parent, a busy single professional, or retiree this book offers realistic and scientifically proven techniques for getting into shape and staying in good health.”

Source: Dr. Eric Heiden and Dr. Massimo Testa


Siemens Introduces New Standard of Care for Breast Ultrasound

Increased information density, automation and intelligent clinical applications take workflow efficiency in ultrasound to an all new level

Siemens Healthcare (www.siemens.com/healthcare) highlights the ACUSON S2000(TM) Automated Breast Volume Scanner (ABVS)(1), the world’s first multi-use, automated volume breast ultrasound system, at the 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA) from November 30 to December 5 at McCormick Place (Booth #922, East Building/Lakeside Center, Hall D) in Chicago. Siemens also demonstrates how Tissue Strain Analytics(2), a new dimension of diagnostic information, and intelligent knowledge-based workflow solutions, empower physicians to leverage ever-increasing imaging information density to achieve greater diagnostic confidence and decreased study time.

According to the New England Journal of Medicine(3), dense breast tissue increases a woman’s risk of breast cancer up to five-fold. While mammography remains the method of choice for breast cancer screening, a study(4) published by the RSNA in 2002 found that the detection rate for nonpalpable, invasive breast cancers increased by 42 percent when mammography was followed by an ultrasound examination.

“I am convinced that Automated Breast Volume Scanning can make a significant contribution in diagnostic confidence for women with dense breast tissue and inconclusive mammograms,” said Klaus Hambuechen, CEO, Ultrasound, Siemens Healthcare. Examinations performed with the ACUSON S2000 ABVS technique generally take less than 15 minutes. “Time well spent if you consider the extended diagnostic capabilities of ultrasound in dense breasts,” he says.

Unique Anatomical Coronal View

The ACUSON S2000 ABVS system automatically and quickly acquires full-field sonographic volumes for comprehensive review and diagnosis of the breast streamlining workflow and reducing operator dependence and variability. The system also features the intuitive, anatomical coronal plane, not available using conventional ultrasound. This view provides a more understandable representation of the global anatomy and architecture of the breast. Semi-automated reporting and comprehensive BI-RADS(R) reporting capabilities further enhance the clinical workflow.

The ACUSON S2000 ABVS has an innovative, mobile in-suite design combining the advanced ACUSON S2000(TM) ultrasound system with a transducer specifically designed for automated ultrasound breast volume imaging. To further optimize high-volume patient care, the system also supports innovative breast imaging applications, such as fatty tissue and eSie Touch(TM) elasticity imaging.

Increased Diagnostic Information for Liver Disease and Other Organs

The world’s first commercially available implementations of Acoustic Radiation Force Imaging (ARFI), Virtual Touch(TM) Tissue Imaging(5) and Virtual Touch Tissue Quantification(6) premiere on the ACUSON S2000 ultrasound system. Similar to a physical palpation exam, these leading-edge technologies represent a new dimension of diagnostic information by interrogating the mechanical strain properties or stiffness of tissue, which may be correlated with pathology.

“Virtual Touch Tissue Imaging adds an independent parameter to our existing morphological diagnostic process,” said Professor William Lees, MD, of the University College London Hospital (UCLH), United Kingdom, who has worked with the technology for over a year now. “The more parameters we have, the more confident our diagnosis can be.”

Complementing the strain analysis is Virtual Touch Tissue Quantification, which is the first and only application to provide a numerical value related to tissue stiffness at a precise anatomical location. The application is highly promising in identifying early stages of liver diseases causing cirrhosis. Early studies show that it proved extremely sensitive in diagnosing fibrosis and distinguishing it from normal liver and cirrhosis.

Knowledge-based Workflow

Siemens will also demonstrate the clinical and economic benefits of knowledge-based workflow applications across their all-new ACUSON ultrasound product line, which automate and streamline a broad range of routine clinical tasks. Using learned pattern recognition from an expert database of thousands of clinical cases, knowledge-based workflow applications recognize anatomical patterns and landmarks and can automatically perform measurements and other routine tasks to achieve a whole new level of accuracy and efficiency. For example, syngo(R) eSieCalcs(TM) native tracing software features proprietary border detection technology to facilitate lesion or anatomical structure boundary segmentation and syngo AutoOB measurements allow automatic biometric measurements of the fetus (BPD, HC, AC, FL, HL, CRL). Knowledge-based workflow applications help to achieve consistent and reproducible measurements with high speed and fidelity across a wide range of applications and users.

To learn more about the Siemens Ultrasound innovations, please visit www.siemens.com/ultrasound. You can also tune in to listen to the “Advances in Medical Imaging” audio features of these and other Siemens Ultrasound news at Reach MD XM157 or www.ReachMD.com. Hosts Dr. Jason Birnholz, president of Diagnostic Ultrasound Consultants in Oakbrook, Ill., and Dr. Beverly Hashimoto, Ultrasound Section Head at Virginia Mason Medical Center in Seattle, cover a wide range of ultrasound topics, including “Sonography Workflow Automation,” “Handheld Ultrasound in the ER,” “Tissue Strain Imaging,” and “3D and 4D Echocardiography in Cardiology.” The program airs every weekday on XM 157 and is also available online at www.reachmd.com/medicalimaging (promo code: Siemens).

(1) 510 (k) pending; not available in the United States
(2) Not available in the United States

(3) N Engl J Med 356;3. Boyd N.F. et Al., Mammographic Density and the Risk and Detection of Breast Cancer

(4) Radiology 2002;225:165-175. Kolb T.M. et Al., Comparison of the Performance of Screening Mammography, Physical Examination, and Breast US and Evaluation of Factors that Influence Them: An Analysis of 27,825 Patient Evaluations

(5) Not available in the United States

(6) Not available in the United States


Do You Know You’re Having a Stroke?

Symptom awareness can improve recovery

Audio and Web Video Resources to accompany this story are available on the Mayo Clinic News Blog. Please see the bottom of this release for details

A Mayo Clinic study shows a majority of stroke patients don’t think they’re having a stroke — and as a result — delay seeking treatment until their condition worsens. The findings appear in the current issue of Emergency Medicine Journal at http://emj.bmj.com/.

Researchers studied 400 patients who were diagnosed at Mayo Clinic’s emergency department with either acute ischemic stroke or a transient ischemic attack (TIA), a temporary interruption of blood flow to part of the brain.

Less than half of the patients — 42 percent — thought they were having a stroke. In fact, most in the study did not go to the emergency room when symptoms appeared. The median time from onset of symptoms to arrival at the hospital was over three and a half hours. Most said they thought the symptoms would simply go away. The delay in seeking medical help was the same among men and women.

When asked how they knew about stroke symptoms, nearly one-fifth said they thought a stroke always came on gradually. Just over half (51.9 percent) said they thought that seeking medical care immediately was important.

Significance of the findings

“Time is crucial in treating stroke,” says Latha Stead, M.D., emergency medicine specialist and lead author of the study. “Each individual’s medical background differs and affects recovery, but in general the sooner a patient experiencing a stroke reaches emergency care, the more likely the stroke can be limited and the condition managed to prevent further damage and improve recovery.” The researchers say their findings clearly indicate that better public understanding of stroke symptoms will lead to a faster response and better outcomes.

What you should know

Strokes can happen quickly or can occur over several hours, with the condition continually worsening. The thrombus or clot that is causing the stroke can frequently be dissolved or disintegrated so blood can again flow to the brain. In such cases, immediate treatment can mean the difference between a slight injury and a major disability. Interestingly only 20.8 percent of the participants knew about such treatment. By use of stents, medications and other technology, physicians can stop a stroke from spreading and greatly limit damage. Stroke symptoms include:

  • Sudden numbness, weakness, or paralysis of your face, arm or leg — usually on one side of the body
  • Sudden difficulty speaking or understanding speech (aphasia)
  • Sudden blurred, double or decreased vision
  • Sudden dizziness, loss of balance or loss of coordination
  • A sudden, severe “bolt out of the blue” headache or an unusual headache, which may be accompanied by a stiff neck, facial pain, pain between your eyes, vomiting or altered consciousness
  • Confusion or problems with memory, spatial orientation or perception

In such cases, a stroke gives no warning. But one possible sign of an impending stroke is a TIA. The signs and symptoms of TIA are the same as for a stroke, but they last for a shorter period — several minutes to a few hours — and then disappear, without leaving apparent permanent effects. You may have more than one TIA, and the signs and symptoms may be similar or different. A TIA indicates a serious risk that a full-blown stroke may follow.

Other Mayo researchers involved in the study were Lekshmi Vaidyanathan, M.B.B.S.; Maria Bellolio, M.D.; Rahul Kashyap, M.B.B.S.; Anjali Bhagra, M.B.B.S.; Rachel Gilmore, M.B.B.Ch.; Wyatt Decker, M.D.; Sailaja Enduri, M.B.B.S.; Shaily Mishra, Ph.D.; Helen Wood, R.N.; Ayman Yassa, M.D.; Ann Hoff, M.D.; and Robert Brown, M.D. Dr. Stead is supported by the Mayo Emergency Medicine Research Career Development Award and Mayo Clinic.

To obtain the latest news releases from Mayo Clinic, go to www.mayoclinic.org/news. MayoClinic.com (www.mayoclinic.com) is available as a resource for your health stories. For more on Mayo Clinic research, go to www.mayo.edu.

To access web video and audio from Dr. Stead, click the link below: http://newsblog.mayoclinic.org/2008/11/24/are-you-having-a-stroke-many-don%E2% 80%99t-know-the-signs-or-seek-treatment/


Study Shows Shocking Cost of Multiple Sclerosis

  • Author: Health Informer
  • Filed under: Health News
  • Date: Nov 25,2008

A study of people living with the devastating effects of multiple sclerosis (MS) has shown the true economic cost of living with the incurable, life-long condition.

The independent research is one of the largest ever studies into the financial impact of MS and has revealed that the cost of being diagnosed with MS is on average nearly GBP17,000 per person. Care provided informally by families accounts for more than 70% of this.

For the 85,000 living with the condition, this works out to be a total expense to the economy of GBP1.4billion, making MS second only to tumours as the most costly brain condition across Europe.

Worse still, the study found that among the nearly 2,000 people surveyed from across the UK, half said they had to leave work due to their MS, pushing the figure to more than GBP25,000 per person when lost employment is added.

Daniel Berry, head of policy and campaigns at the MS Society, said: “This research shows the shocking cost of living with MS.

“It has been proven to be economically viable to keep people with MS as healthy as possible and in work for as long as possible and this study shows how cutting corners in health and social care is counter productive.

“At a time when the government is running headlong into even more debt, these figures underline the enormous costs of inaction. Long term investment in research and in support for carers would pay dividends for people living with MS and for the whole economy.”

The Costs of MS study analyses the economic cost, quality of life and disability associated with MS and the independent research was carried out for the MS Society by Dr Paul McCrone from Kings College London and published in the peer reviewed journal of Pharmacoeconomics.

Dr McCrone said: “The costs associated with MS are substantial. Most of the service costs are hidden as they represent care provided by family members.

“It is crucial that evaluations of any new treatments or forms of care should assess their impact on carer costs as well as the costs of statutory services.”

The study has shown that the cost of MS can be broken down as follows:

  • Informal care GBP1,021 million (72%)
  • Professional care GBP245 million (17.2%)
  • Medication GBP115.5 million (8.1%)
  • Aids and adaptations GBP37.1million (2.30%)
  • Medical tests GBP5.7million (0.4%)

With bills for care from family and friends estimated to be worth more than a billion pounds alone and the cost of home adaptations running into tens of millions, it is no surprise that MS Society grants for financial advice and assistance are in high demand.

For more information, see http://www.mssociety.org.uk

Case studies – contact MS Society press office for interviews

Leonie from Derbyshire is married and has two children.

She has lived with MS for almost 20 years and as a result of worsening symptoms had to give up her role as the main breadwinner in her household.

She took early retirement aged 39 from her job as a school bursar as a result of the unpredictable MS.

This means her family is in a much worse position financially, but her stress-related MS relapses have lessened.

Fay from Nottinghamshire has a nine-year-old son who is her main carer.

She was diagnosed with MS five years ago and two major relapses mean that she now has to work part time.

She finds it hard to pay the bills and had to rely on her mother to fund an electric wheelchair that she needs to get up the hill on which she lives.

Due to constantly feeling cold as a result her MS, Fay has the heating on continuously and has to do more washing due to continence issues related to her condition.

Her electricity bills are always high because of the need to charge her electric wheelchair at night.

Notes:

  • The survey statistics are based on a large (1,942) sample, with a very good (48.9%) response rate
  • The McCrone study suggests that the average cost of MS is GBP16,794 per person. This increases to GBP25,310 for people of working age, when factoring-in the costs of lost employment
  • The survey demonstrated that people with MS in the UK have a relatively low quality of life, using the recognised QOL measurement
  • This work looks at the economic costs of MS, not the costs in terms of worry, discomfort and pain to people living with the condition
  • It is important to quantify the total costs of conditions such as MS, so that policy makers have the full information to work with when making policy decisions. This is especially relevant when assessments are made of new treatments that can people keep people as healthy as possible for as long as possible
  • The average respondent to the survey was a 54 year old married woman with adult children, retired due to ill health.

Employment

  • 50% of the sample were retired due to ill health
  • 21.3% were in work, but half of those were only part time
  • 7.5% were unemployed – compared to an average unemployment rate in 2007 of 5.4%.
  • 9.5% retired and 8.8% housewife/husband

The MS Society

  • The MS Society (http://www.mssociety.org.uk) is the UK’s largest charity dedicated to supporting everyone whose life is touched by MS, providing respite care, an award-winning freephone helpline (0808-800-8000), specialist MS nurses and funds more than 50 vital MS research projects in the UK.
  • Multiple sclerosis is the most common disabling neurological condition affecting young adults and an estimated 85,000 people in the UK have MS.
  • MS is the result of damage to myelin – the protective sheath surrounding nerve fibres of the central nervous system – which interferes with messages between the brain and the body.
  • For some people, MS is characterised by periods of relapse and remission while for others it has a progressive pattern.
  • Symptoms range from loss of sight and mobility, fatigue, depression and cognitive problems. There is no cure and few effective treatments.


Bulimia Can’t Hide From This Dentist

  • Author: Health Informer
  • Filed under: Health News
  • Date: Nov 25,2008

Bulimics are notorious for hiding their disease. Princess Diana, a victim of the disease said, “…it’s like a secret disease. You inflict it upon yourself…” Hiding the signs becomes a way of life, until the bulimic goes to the dentist that is.

“The mouth is like an open book, the signals that something is wrong are everywhere – swollen salivary glands, stomach-acid etched teeth,” says dentist Dr. Brian McKay, author of the new book, “Bulimia Is a Dental Disease.” Left untreated the result is tooth and bone loss, abscesses, gum disease and the real threat of heart damage as studies have shown the direct link between oral and heart health.

“These are more than just dental patients, they are real people in pain suffering from mental illness that manifests itself through bulimic purging behavior,” says McKay. The book, the first that links dental disease and bulimia, explores the psychological causes of bulimia and purging disorder, offering an innovative non-judgmental solution that releases the smile within these victims allowing them to achieve peace.

“26% of all bulimia is first diagnosed by a dentist,” says McKay, citing a study by the Institute of Dental Research. Using examples from his own practice, McKay illustrates how a victim struggles and how dentists everywhere can lead the charge to treat these victims before it is too late. “Denial and secrecy are hallmarks of the disorder, there can be no denial or secrecy when a qualified dentist exams the patient’s mouth.”

“We need a change in the Standard of Care,” says McKay. “Dentists must form alliances with eating disorder professionals. Together we can treat both the mental and oral aspects of this disease and the result should be a higher success rate. There is nothing more inviting than seeing someone smile again.”

About Dr. McKay:

Brian McKay, DDS graduated from the USC Dental School before establishing his dental practice in Seattle. McKay achieved international distinction as a Founding Faculty member, lecturer and Faculty Leader of the world-renowned Pacific Aesthetic Continuum (PAC-Live) based at the UofP Dental School in San Francisco. After leaving PAC-Live, he has concentrated on developing an innovative non-judgmental approach to the practice of dentistry while lecturing and writing. He authored the book, “Bulimia Is A Dental Disease” (Xlibris Press, 2008).

Source: The Smile Within


Today, prescription drugs are the first choice for medical intervention in treating 88 percent of patients suffering chronic conditions. The 50 percent of Americans treated for a chronic condition account for 96 percent of all prescription drug spending and 75 percent of all medical costs. A proprietary new pharmacy model developed over three years by Medco Health Solutions, Inc. significantly reduces critical gaps in care for patients with chronic and complex diseases and lowers overall medical costs, according to an independently validated set of analyses released today.

“The data could not be more compelling. In an era where we have seen huge increases in the number of patients with chronic disease, an evidence-based protocol model leveraging the Medco Therapeutic Resource Centers(R), has proven critical to improving the effectiveness of treatment and driving down the cost of health care. We’ve invented an end-to-end capability that yields better outcomes, both clinically and financially,” said Medco’s Chairman and Chief Executive Officer, David B. Snow Jr.

Rigorous large-scale analyses were conducted by Medco, and the associated clinical content and general analytical processes were independently reviewed and validated by the actuarial and consulting firm, Milliman Inc.

The first analysis evaluated 600,000 patients to identify gaps in care in their treatment of diabetes, and pulmonary and heart disease. The gaps in care ranged from deviations in nationally accepted clinical protocols, including incorrect and over-prescribing, to patients failing to appropriately follow their physician’s instructions.

Key findings over a 90-day study period:

  • For hypertension, Medco closed 81 percent of the clinical gaps related to patients not adherent to diuretic medications.
  • For hyperlipidemia, Medco closed 74 percent of the clinical gaps related to patients not adherent to statin medications to lower cholesterol.
  • Medco closed 24 percent of the gaps related to diabetes patients under insulin treatment who were not monitoring their blood sugars.
  • Medco closed 7 percent of the gaps related to diabetes patients who, contrary to evidence-based protocols, never had a statin prescribed.

The second analysis, which was a review of two years of pharmacy and medical data, concluded that using the Medco Therapeutic Resource Centers (TRC) substantially reduced overall health care costs for select patients with hypertension by improving adherence to evidence-based standards. Per patient health care costs for hypertensive patients who either were primarily or exclusively using the TRCs was $10,509 annually, a $700 per-patient reduction in health care costs compared to the traditional pharmacy care model.

“In addition to elevating clinical care to improve patient wellness, this reduction in overall health care costs represents a significant breakthrough, and serves as a baseline for driving further improvement through our Six Sigma quality protocol, which is a foundation in achieving the potential of evidence-based medicine,” said Kenneth O. Klepper, Medco president and chief operating officer.

The third analysis compared compliance with evidence-based diabetes quality-of-care metrics for patients enrolled in the TRCs compared with those patients obtaining standard pharmacy care services.

Key findings comparing TRCs to traditional pharmacy channels revealed:

  • More than 78 percent of TRC patients were adherent to their diabetes medications, compared to only 56.5 percent.
  • More than 83 percent of TRC patient with diabetes were adherent to antihypertensive medications compared with 65.4 percent.
  • More than 80 percent of TRC patients with diabetes were adherent to cholesterol-lowering medications compared with 62.4 percent.
  • Of patients with diabetes needing to be on a cholesterol medication 76.6 percent of TRC patients were on a cholesterol medication compared with 63 percent.

Separately, Medco also evaluated the over-use of short-acting rescue inhalers for patients with asthma. Using a protocol-driven approach, the percentage of patients obtaining more than the recommended single canister of the rescue inhaler was reduced from 22 percent to 7 percent. This demonstrates the ability of the TRCs to identify and institute protocols to reduce medication waste and, at the same time, improve patient outcomes.

“These results are great news for those treating patients with chronic illness; they show that barriers to adherence, which have been a persistent and difficult problem, can be overcome with the right therapeutic approach,” said Klepper. “Patient counseling by specialist pharmacists appears to have a high degree of success in closing many of the gaps in care that need to be eliminated in order to improve clinical outcomes and lower overall health care costs. This was key to establish high levels of transparency and accountability to our clients.”

The TRC approach enlists specialist pharmacists guided by nationally recognized protocols in specific chronic diseases, as well as access to integrated data systems that allow them to leverage both pharmacy and medical information to better assess the patient’s condition and recommended course of treatment. These specialist pharmacists are uniquely able to provide in-depth counseling to patients to close a range of clinical gaps in care and, when necessary, to inform their collaborative discussions with the patient’s physicians.

“The focus today in health care is on developing a fully-wired system. This system is already a reality at Medco,” said Snow. “Our TRC model allows us to aggregate, in real time, 100 percent of prescription drug data and complementary medical information to identify and close gaps in care, drive proactive improvements, and prevent harmful drug interactions that also add to our nation’s huge health care bill.”

Lower Costs; Better Outcomes

These TRC analyses add to the growing body of evidence that overall cost of caring for patients decreases as the gaps in pharmacy care are closed. A separate Medco study published in the journal Medical Care, found that average yearly combined pharmacy and medical costs for the patients who were not adhering to evidence-based treatment protocols was $8,867 compared to $4,570 for patients adherent to their treatment regimen. On average, each diabetes patient not properly adhering to recommended therapy increases health care costs by as much as $2,200 per year.

“There is no denying that the unnecessary costs created by clinical gaps in prescription drug care are huge — but human costs are even higher. When people with diabetes fail to follow their medication or monitor their blood sugar, they risk blindness, amputations, renal failure and other serious complications. People with high blood pressure risk heart attack or stroke if not properly controlled through drug therapy,” said Dr. Peter Juhn, president of Medco’s TRC pharmacy practice. “Developing a care model that identifies at-risk patients and effectively intervenes through counseling and education is critical for preventing these avoidable consequences.”

“These results validate our belief that an advanced pharmacy model drives superior financial and clinical benefits,” Snow said. “We have already begun evaluating ways in which we can work with community pharmacies to bring the benefits and solutions we have created in the TRCs to the patients they serve. We are also working with policymakers in Washington to share what we have learned in hopes that it can serve as a model contributing to the many health care reform efforts under consideration today.”

Medco

Medco Health Solutions, Inc. is the nation’s leading pharmacy benefit manager based on its 2007 total net revenues of more than $44 billion. Medco’s prescription drug benefit programs, covering approximately one-in-five Americans, are designed to drive down the cost of pharmacy health care for private and public employers, health plans, labor unions and government agencies of all sizes, for individuals served by the Medicare Part D Prescription Drug Program, and those served by Medco’s specialty pharmacy segment, Accredo Health Group. Medco, the world’s most advanced pharmacy(R), is positioned to serve the unique needs of patients with chronic and complex conditions through its Medco Therapeutic Resource Centers(R), including its enhanced diabetes pharmacy care practice through the Liberty acquisition. Medco is the highest-ranked independent pharmacy benefit manager on the 2008 Fortune 100 list. On the Net: http://www.medcohealth.com/.

Milliman

Milliman is among the world’s largest independent actuarial and consulting firms. Founded in Seattle in 1947 as Milliman & Robertson, the company currently has 49 offices in key locations worldwide. Milliman employs more than 2000 people, with a professional staff of more than 1000 qualified consultants and actuaries, including specialists ranging from clinicians to economists. The firm has consulting practices in healthcare, employee benefits, property and casualty insurance, life insurance, and financial services. Milliman serves the full spectrum of business, financial, government, union, education, and nonprofit organizations. For further information, visit www.milliman.com.